Effects of Surface Morphology of <svg     style="vertical-align:-4.32007pt;width:84.324997px;" id="M1" height="21" version="1.1" viewBox="0 0 84.324997 21" width="84.324997"  xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg">
	
		
			<g transform="matrix(.022,-0,0,-.022,.062,15.55)"><path id="x1D419" d="M608 242h26l-27 -242h-579v16l382 623l-83 -1q-117 -2 -162 -33q-45 -30 -78 -136h-28l22 207h523v-16l-379 -625h83q146 0 202 40q27 19 45 45q19 26 26 47q9 21 27 75z" /></g><g transform="matrix(.022,-0,0,-.022,15.014,15.55)"><path id="x1D427" d="M539 24v-24h-234v24q25 3 35.5 16.5t10.5 43.5v237q0 85 -51 85q-36 0 -70 -34q-17 -17 -17 -24v-264q0 -29 10.5 -42.5t37.5 -17.5v-24h-240v24q33 7 43 19t10 44v289q0 32 -10 44t-43 17v24h191v-75h1q49 87 142 87q62 0 98.5 -38.5t36.5 -103.5v-247q0 -34 10 -46&#xA;t39 -14z" /></g><g transform="matrix(.022,-0,0,-.022,27.478,15.55)"><path id="x1D400" d="M689 25v-25h-322v25l32 3q46 4 46 33q0 31 -46 136h-225l-13 -34q-31 -78 -31 -97q0 -36 81 -41v-25h-202v25q36 6 53 28q18 22 46 92l221 545h28l222 -522q36 -87 58 -117q21 -26 52 -26zM189 236h195l-101 243z" /></g><g transform="matrix(.022,-0,0,-.022,43.662,15.55)"><path id="x1D425" d="M256 24v-24h-240v24q51 4 51 63v500q0 61 -52 65v24h191v-589q0 -62 50 -63z" /></g>

			<g transform="matrix(.016,-0,0,-.016,49.887,20.938)"><path id="x1D7D0" d="M453 211h25l-46 -211h-415v23q97 102 151 166q42 49 81 110q51 78 51 148q0 56 -31.5 91.5t-87.5 35.5q-77 0 -122 -90h-28q67 204 223 204q82 0 132 -49.5t50 -133.5q0 -110 -114 -218l-162 -154h140q82 0 107 13q27 13 46 65z" /></g>

			<g transform="matrix(.022,-0,0,-.022,58.362,15.55)"><path id="x1D40E" d="M743 335q0 -156 -100 -255q-99 -99 -255 -99q-155 0 -254 99t-99 254q0 159 101 258q100 99 258 99q151 0 250 -101q99 -100 99 -255zM566 328q0 160 -46.5 245t-134.5 85q-83 0 -128 -86t-45 -242q0 -158 46 -237t132 -79t131 80t45 234z" /></g>

			<g transform="matrix(.016,-0,0,-.016,75.8,20.938)"><path id="x1D7D2" d="M476 255v-111h-64v-144h-145v144h-248v113l313 431h80v-433h64zM60 255h208v294z" /></g>

		
	
</svg> Ceramic Materials on Osteoblastic Cells Responses

doi:10.1155/2013/361249

Journal Menu

Journal of Nanomaterials
Volume 2013 (2013), Article ID 361249, 7 pages
http://dx.doi.org/10.1155/2013/361249

Research Article

Effects of Surface Morphology of Ceramic Materials on Osteoblastic Cells Responses

José Luis Suárez-Franco,¹ Manuel García-Hipólito,² Miguel Ángel Surárez-Rosales,² José Arturo Fernández-Pedrero,¹ Octavio Álvarez-Fregoso,² Julio Alberto Juárez-Islas,² and Marco Antonio Álvarez-Pérez^1,3

¹Laboratorio de Bioingeniería de Tejidos, Facultad de Odontología, Universidad Nacional Autónoma de México, Coyoacán, 04510 Ciudad de México, DF, Mexico
²Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Coyoacán, 04510 Ciudad de México, DF, Mexico
³Tissue Bioengineering Laboratory, Division of Research and Postgraduate Studies, Faculty of Dentistry, National Autonomous University of Mexico (UNAM), Circuito Exterior s/n, Coyoacan, 04510 Mexico City, DF, Mexico

Received 5 September 2012; Revised 16 January 2013; Accepted 17 January 2013

Academic Editor: Nabeen Kumar Shrestha

Copyright © 2013 José Luis Suárez-Franco et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Ceramic scaffolds are widely studied in the tissue engineering field due to their potential in medical applications as bone substitutes or as bone-filling materials. The purpose of this study was to investigate the effect of surface morphology of nanostructure thin films of ZnAl₂O₄ prepared by spray pyrolysis and bulk pellets of polycrystalline ZnAl₂O₄ prepared by chemical coprecipitation reaction on the in vitro cell adhesion, viability, and cell-material interactions of osteoblastic cells. Our result showed that cell attachment was significantly enhanced from 60 to 80% on the ZnAl₂O₄ nanostructured material surface when compared with bulk ceramic surfaces. Moreover, our results showed that the balance of morphological properties of the thin film nanostructure ceramic improves cell-material interaction with enhanced spreading and filopodia with multiple cellular extensions on the surface of the ceramic and enhancing cell viability/proliferation in comparison with bulk ceramic surfaces used as control. Altogether, these results suggest that zinc aluminate nanostructured materials have a great potential to be used in dental implant and bone substitute applications.