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Journal of Nanomaterials
Volume 2013 (2013), Article ID 450483, 9 pages
http://dx.doi.org/10.1155/2013/450483
Research Article

Obtaining of Sol-Gel Ketorolac-Silica Nanoparticles: Characterization and Drug Release Kinetics

1Laboratorio de Nanotecnología y Nanomedicina, Departamento de Atención a la Salud, Universidad Autónoma Metropolitana Xochimilco, Calzada del Hueso 1100, Col. Villa Quietud, Delegación Coyoacán, 04960 México, DF, Mexico
2Laboratorio de Nanotecnología, Instituto Nacional de Neurología y Neurocirugía “Manuel Velasco Suárez”, Avenida Insurgentes sur 3877, Col. La Fama, 14269 Tlalpan, DF, Mexico
3Department of Chemical and Biomolecular Engineering, Tulane University, New Orleans, LA 70118, USA
4Facultad de Ciencias, Universidad Nacional Autónoma de México, Avenida Universidad 3000, Circuito Exterior S/N Delegación Coyoacán, Ciudad Universitaria, 04510 México, DF, Mexico

Received 24 August 2012; Accepted 1 November 2012

Academic Editor: Yan-Yan Song

Copyright © 2013 T. M. López Goerne et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) are among most commonly prescribed medications worldwide. NSAIDs play an important role due to their pronounced analgesic potency, anti-inflammatory effects, and lesser side effects compared to opioids. However, adverse effects including gastrointestinal and cardiovascular effects seriously complicate their prolonged use. In the present work we prepare SiO2-based nanoparticles with ketorolac, for controlled release proposes. The nanomaterials were prepared by the sol-gel technology at acidic conditions and two different water/alcoxide ratios were used. FTIR spectroscopy was performed in order to characterize the solids and drug-SiO2 interactions. Thermal analysis and nitrogen adsorption isotherms showed thermal stability of the drug and confirmed the presence of particles with high surface area. Transmission electron micrographies of the samples showed the nanosize particles (20 nm) forming aggregates. Drug release profiles were collected by means of UV-Vis spectroscopy and kinetic analysis was developed. Release data were fitted and 1 : 8 sample showed a sustained release over ten hours; 90% of the drug was delivered at the end of the time.