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Journal of Nanomaterials
Volume 2013 (2013), Article ID 467878, 6 pages
http://dx.doi.org/10.1155/2013/467878
Research Article

Effect of SPIO Nanoparticle Concentrations on Temperature Changes for Hyperthermia via MRI

1Photochemistry and Nanochemistry, National Institute of Laser Enhanced Science (NILES), Cairo University, P.O. Box 12613, Giza, Egypt
2Children’s Cancer Hospital, Cairo 57357, Egypt

Received 25 November 2012; Accepted 23 February 2013

Academic Editor: Mohamed Bououdina

Copyright © 2013 Alsayed A. M. Elsherbini and Ahmed El-Shahawy. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Magnetic nanoparticles (MNPs) are being developed for a wide range of biomedical applications. In particular, hyperthermia involves heating the MNPs through exposure to an alternating magnetic field (AMF). These materials offer the potential for selectively by heating cancer tissue locally and at the cellular level. This may be a successful method if there are enough particles in a tumor possessing sufficiently high specific absorption rate (SAR) to deposit heat quickly while minimizing thermal damage to surrounding tissue. The current research aim is to study the influence of super paramagnetic iron oxides Fe3O4 (SPIO) NPs concentration on the total heat energy dose and the rate of temperature change in AMF to induce hyperthermia in Ehrlich carcinoma cells implanted in female mice. The results demonstrated a linearly increasing trend between these two factors.