Table 3: Nanoparticle cancer therapeutics undergoing clinical investigation.

Product/agent Nanoplatform Indication Status Company Cyclosert Cyclodextrin nanoparticles (Cyclodextrin NP/SiRNA) Solid tumors Phase I Insert Therapeutics (now Calando Pharmaceuticals) CRLX101 Cyclodextrin NPs/Camptothecin Various cancers Phase II Cerulean Pharma S-CKD602 PEGylated liposomal CKD602 (topoisomerase inhibitor) Various cancers Phase I/II Alza Corporation CPX-1 Liposomal irinotecan Colorectal cancer Phase II Celator Pharmaceuticals CPX-351 Liposomal cytarabine and daunorubicin Acute myeloid leukemia Phase I Celator Pharmaceuticals LE-SN38 Liposomal SN38 Colorectal cancer Phase II Neopharm INGN-401 Liposomal/FUS1 Lung cancer Phase I Introgen NC-6004 Polymeric nanoparticle (PEG-polyaspartate) formulation of cisplatin Various cancers Phase I NanoCarrier Co. NK-105 Polymeric nanoparticle (PEG-polyaspartate) formulation of paclitaxel Various cancers Phase II Nippon Kayaku Co. Ltd. NK-911 Polymeric nanoparticle (PEG-polyaspartate) formulation of doxorubicin Various cancers Phase I Nippon Kayaku Co. Ltd. NK-012 Polymeric micelle of SN-38 Various cancers Phase II Nippon Kayaku Co. Ltd. SP1049C Glycoprotein of doxorubicin Various cancers Phase II Supratek Pharma Inc. SPI-077 PEGylated liposomal cisplatin Head/neck and lung cancer Phase II Alza Corporation ALN-VSP Lipid nanoparticle formulation of siRNA Liver cancer Phase I Alnylam Pharmaceuticals OSI-7904L Liposomal thymidylate synthase inhibitor Various cancers Phase II OSI Pharmaceuticals OSI-211 Liposomal lurtotecan Various cancers Phase II OSI Pharmaceuticals Combidex Iron oxide Tumor imaging Phase III Advanced Magnetics Aurimune Colloidal gold/TNF Solid tumors Phase II CytImmune Sciences SGT-53 Liposome Tf antibody/p53 gene Solid tumors Phase I SynerGene Therapeutics BIND-014 PLGA/PLA NPs/Docetaxel Prostate cancer and others Phase I BIND Biosciences AuroLase Gold-coated silica NPs Head and neck cancer Phase I Nanospectra Biosciences Rexin-G Targeting protein tagged phospholipid/microRNA-122 Sarcoma, osteosarcoma, pancreatic cancer, and other solid tumor Phase II/III (Fast Track Designation, Orphan Drug Status Acquired) in USA fully approved in Philippine Epeius Biotechnologies Corp. ThermoDox Heat-activated liposomal encapsulation of doxorubicin Breast cancer, primary liver cancer Approved for Breast Cancer; Phase III for primary liver cancer Celsion BIND-014 Polymeric nanoparticle formulation of docetaxel Various cancers Phase I BIND Bioscience SGT53-01 Transferrin targeted liposome with p53 gene Solid tumors Phase I SynerGene Therapeutics PEG-PGA and DON PEG-glutaminase combined with glutamine antimetabolite 6-diazo-5-oxo-l-norleucine (DON) Various cancers Phase I/II EvaluatePharma PEG-IFNα2a PEG-asys Melanoma, chromic myeloid leukemia, and renal-cell carcinoma Phase I/II Genentech PEG-IFNα2b PEG-Intron Melanoma, multiple myeloid, and renal-cell carcinoma Phase I/II Merck ADI-PEG20 PEG-arginine deiminase Hepatocellular carcinoma Phase I Polaris