Table 3: Nanoparticle cancer therapeutics undergoing clinical investigation.

Product/agentNanoplatformIndicationStatusCompany

CyclosertCyclodextrin nanoparticles (Cyclodextrin NP/SiRNA)Solid tumorsPhase IInsert Therapeutics
(now Calando Pharmaceuticals)
CRLX101Cyclodextrin NPs/CamptothecinVarious cancersPhase IICerulean Pharma
S-CKD602PEGylated liposomal CKD602 (topoisomerase inhibitor)Various cancersPhase I/IIAlza Corporation
CPX-1Liposomal irinotecanColorectal cancerPhase IICelator Pharmaceuticals
CPX-351Liposomal cytarabine and daunorubicinAcute myeloid leukemiaPhase ICelator Pharmaceuticals
LE-SN38Liposomal SN38Colorectal cancerPhase IINeopharm
INGN-401Liposomal/FUS1Lung cancerPhase IIntrogen
NC-6004Polymeric nanoparticle (PEG-polyaspartate) formulation of cisplatinVarious cancersPhase INanoCarrier Co.
NK-105Polymeric nanoparticle (PEG-polyaspartate) formulation of paclitaxel Various cancersPhase IINippon Kayaku Co. Ltd.
NK-911Polymeric nanoparticle (PEG-polyaspartate) formulation of doxorubicinVarious cancersPhase INippon Kayaku Co. Ltd.
NK-012Polymeric micelle of SN-38Various cancersPhase IINippon Kayaku Co. Ltd.
SP1049CGlycoprotein of doxorubicinVarious cancersPhase IISupratek Pharma Inc.
SPI-077PEGylated liposomal cisplatinHead/neck and lung cancerPhase IIAlza Corporation
ALN-VSPLipid nanoparticle formulation of siRNALiver cancerPhase IAlnylam Pharmaceuticals
OSI-7904LLiposomal thymidylate synthase inhibitorVarious cancersPhase IIOSI Pharmaceuticals
OSI-211Liposomal lurtotecanVarious cancersPhase IIOSI Pharmaceuticals
CombidexIron oxideTumor imagingPhase IIIAdvanced Magnetics
AurimuneColloidal gold/TNFSolid tumorsPhase IICytImmune Sciences
SGT-53Liposome Tf antibody/p53 geneSolid tumorsPhase ISynerGene Therapeutics
BIND-014PLGA/PLA NPs/DocetaxelProstate cancer and othersPhase IBIND Biosciences
AuroLaseGold-coated silica NPsHead and neck cancerPhase INanospectra Biosciences
Rexin-GTargeting protein tagged phospholipid/microRNA-122Sarcoma, osteosarcoma, pancreatic cancer, and other solid tumorPhase II/III (Fast Track Designation, Orphan Drug Status Acquired) in USA fully approved in PhilippineEpeius Biotechnologies Corp.
ThermoDoxHeat-activated liposomal encapsulation of doxorubicinBreast cancer, primary liver cancerApproved for Breast Cancer; Phase III for primary liver cancerCelsion
BIND-014Polymeric nanoparticle formulation of docetaxelVarious cancers Phase IBIND Bioscience
SGT53-01Transferrin targeted liposome with p53 geneSolid tumorsPhase ISynerGene Therapeutics
PEG-PGA and DONPEG-glutaminase combined with glutamine antimetabolite 6-diazo-5-oxo-l-norleucine (DON)Various cancersPhase I/IIEvaluatePharma
PEG-IFNα2aPEG-asysMelanoma, chromic myeloid leukemia, and renal-cell carcinomaPhase I/IIGenentech
PEG-IFNα2bPEG-IntronMelanoma, multiple myeloid, and renal-cell carcinomaPhase I/IIMerck
ADI-PEG20PEG-arginine deiminaseHepatocellular carcinomaPhase IPolaris