Nanoparticle technology for transcutaneous delivery of drug agents to intact or wounded skin leading to improved wound outcomes. (a) Transepithelial delivery of nanoparticles is limited by the poor penetration through the protective stratum corneum. Transappendageal nanoparticle delivery through hair follicle offers potential for treatment of conditions where skin is intact. ((b)-(c)) Incorporation of drug carrying nanoparticles into dressings and scaffolds allows controlled sustained release of biologically active agents into open wounds intradermally hence resulting in improved healing and reduced scarring.
