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Journal of Nanomaterials
Volume 2013 (2013), Article ID 893970, 7 pages
http://dx.doi.org/10.1155/2013/893970
Research Article

Magnetic Properties and Biological Activity Evaluation of Iron Oxide Nanoparticles

1Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari, Sector 5, Bucharest, Romania
2Emergency Hospital Floreasca, Bucharest 5, Calea Floreasca Nr 8, Sector 1, Bucharest, Romania
3National Institute of Materials Physics, 105 bis Atomistilor, P.O. Box MG 07, 077125 Bucuresti-Magurele, Romania
4Faculty of Physics, University of Bucharest, 405 Atomistilor, CP MG-1, 077125 Magurele, Romania
5ISTO, Université d'Orléans, Orléans Cedex 02, 45067, France
6Microbiology Department, Faculty of Biology, University of Bucharest, Aleea Portocalelor 1-3, 60101 Bucharest, Romania
7Institute of Virology, Antiviral Therapy Department “Stefan S. Nicolau”, 285 Mihai Bravu, 030304 Bucharest, Romania

Received 14 March 2013; Revised 7 June 2013; Accepted 8 June 2013

Academic Editor: Anjan Barman

Copyright © 2013 Alina Mihaela Prodan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of this study was to provide information about the biological properties of iron oxide nanoparticles (IO-NPs) obtained in an aqueous suspension. The IO-NPs were characterized by transmission electron microscopy (TEM). Analysis of hysteresis loops data at room temperature for magnetic IO-NPs sample indicated that the IO-NPs were superparamagnetic at room temperature. The calculated saturation magnetization for magnetic iron oxide was = 18.1 emu/g. The antimicrobial activity of the obtained PMC-NPs was tested against Gram-negative (Pseudomonas aeruginosa 1397, Escherichia coli ATCC 25922), Gram-positive (Enterococcus faecalis ATCC 29212, Bacillus subtilis IC 12488) bacterial as well as fungal (Candida krusei 963) strains. The obtained results suggested that the antimicrobial activity of IO-NPs is dependent on the metallic ions concentrations and on the microbial growth state, either planktonic or adherent. The obtained IO-NPs exhibited no cytotoxic effect on HeLa cells at the active antimicrobial concentrations.