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Journal of Nanomaterials
Volume 2013 (2013), Article ID 980857, 6 pages
http://dx.doi.org/10.1155/2013/980857
Research Article

The Development of Conductive Nanoporous Chitosan Polymer Membrane for Selective Transport of Charged Molecules

Department of Biomedical Engineering, Ming Chuan University, 5 De Ming Road, Gui Shan District, Taoyuan County 333, Taiwan

Received 23 October 2012; Accepted 19 December 2012

Academic Editor: Woo Lee

Copyright © 2013 Pei-Ru Chen and Yun-Ju Chuang. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We present the development of conductive nanoporous CNT/chitosan membrane for charge-selective transport of charged molecules, carboxylfluorescein (CF), substance P, and tumor necrosis factor-alpha (TNF-α). The membrane was made porous and conductive via gelatin nanoparticle leaching technique and addition of carbon nanotubes, respectively. These nanoporous membranes discriminate the diffusion of positive-charged molecules while inhibiting the passage of negative-charged molecules as positive potential was applied. The permeation selectivity of these membranes is reversed by converting the polarity of applied potential into negative. Based on this principle, charged molecules (carboxylfluorescein, substance P, and TNF-α) are successfully filtered through these membranes. This system shows 30 times more selective for CF than substance P as positive potential was applied, while 2.5 times more selective for substance P than CF as negative potential was applied.