Research Article
Nanocrystallization of the Pharmaceutically Active Agent Genipin by an Emulsion Solvent Evaporation Method
Table 1
Factors and levels of the single-factor experiments when one variable factor and others are fixed.
| | Factor | (A) | (B) | (C) | (D) | (E) | (F) | (G) |
| | Levels | Concentration of poloxamer 188 () | The proportion of water to organic phase (v/v) | Homogenate speed (rpm) | Homogenate time (min) | Homogenization pressure (bar) | Homogenization times | The proportion of genipin to mannitol (m/m) |
| | 1 | 1 | 9 : 1 | 5000 | 1 | 400 | 3 | 1 : 3 | | 2 | 2 | 10 : 1 | 7500 | 3 | 600 | 6 | 1 : 5 | | 3 | 3 | 11 : 1 | 10000 | 5 | 800 | 9 | 1 : 7 | | 4 | 4 | 12 : 1 | | 7 | | 12 | 1 : 9 | | 5 | 5 | 13 : 1 | | 9 | | | | | 6 | | 14 : 1 | | 11 | | | | | 7 | | 15 : 1 | | | | | | | 8 | | 16 : 1 | | | | | | | 9 | | 17 : 1 | | | | | | | 10 | | 18 : 1 | | | | | |
|
|
