Therapeutic Potential of Inorganic Nanoparticles for the Delivery of Monoclonal Antibodies

Figure 1

The structural elements of IgG. (a) The two identical Fv (variable fragment) domains bind to the target protein with high specificity. The Fc (constant fragment) domain binds to the Fc receptor of immune cells, triggering effector functions, including CDC and ADCC. LC = light chain, HC = heavy chain, CDR = complementarity determining region, CL = light chain constant region, CH = heavy chain constant region, FR = framework, VL = light chain variable region, VH = heavy chain variable region. (b) IgG murine sequence can be replaced with human sequence to reduce immunogenicity. Commercially available mAbs include chimeric, humanised, and human IgG. Adapted from Maynard and Georgiou, 2000 [1].

(a)

(b)