Caffeic Acid Phenethyl Ester Loaded PLGA Nanoparticles: Effect of Various Process Parameters on Reaction Yield, Encapsulation Efficiency, and Particle Size

Table 2

Effect of process parameters on the reaction yield, encapsulation efficiency, mean particle size, PDI, and zeta potential.

Particle number	Reaction yield (%)	Encapsulation efficiency (%)	Size (nm)	PDI	Zeta potential (mV)
NP 1	39 ± 7	60 ± 3	218 ± 9	0.077 ± 0.005	−22.4 ± 0.7
NP 2	40 ± 6	76 ± 4	208 ± 8	0.065 ± 0.006	−18.7 ± 0.3
NP 3	48 ± 7	86 ± 5	214 ± 8	0.101 ± 0.008	−18.1 ± 1.0
NP 4	49 ± 6	89 ± 2	207 ± 10	0.055 ± 0.005	−19.2 ± 1.3
NP 5	53 ± 5	92 ± 5	214 ± 9	0.079 ± 0.003	−17.7 ± 1.6
NP 6	74 ± 7	91 ± 5	469 ± 15	0.461 ± 0.038	−16.3 ± 1.8
NP 7	80 ± 8	91 ± 3	324 ± 10	0.113 ± 0.007	−20.2 ± 3.1
NP 8	64 ± 6	86 ± 3	246 ± 12	0.119 ± 0.005	−19.6 ± 0.7
NP 9	63 ± 9	83 ± 5	243 ± 13	0.138 ± 0.010	−15.8 ± 1.9
NP 10	68 ± 8	84 ± 7	260 ± 7	0.139 ± 0.006	−14.0 ± 2.9
NP 11	70 ± 7	85 ± 6	284 ± 9	0.177 ± 0.005	−15.6 ± 1.8
NP 12	68 ± 6	84 ± 3	271 ± 7	0.150 ± 0.009	−14.2 ± 1.8
NP 13	64 ± 8	80 ± 5	248 ± 8	0.164 ± 0.008	−12.7 ± 1.3
NP 14	15 ± 4	65 ± 4	180 ± 7	0.087 ± 0.005	−18.7 ± 2.0
NP 15	7 ± 4	66 ± 2	158 ± 9	0.057 ± 0.002	−16.6 ± 1.8
NP 16	12 ± 6	64 ± 4	158 ± 10	0.103 ± 0.008	−16.2 ± 2.0
NP 17	15 ± 7	83 ± 4	187 ± 6	0.143 ± 0.014	−16.3 ± 2.6
NP 18	83 ± 6	84 ± 6	215 ± 5	0.128 ± 0.018	−17.5 ± 1.6
NP 19	86 ± 7	81 ± 4	404 ± 9	0.403 ± 0.042	−21.4 ± 2.5
NP 20	92 ± 5	85 ± 5	437 ± 9	0.499 ± 0.066	−19.4 ± 2.0
Optimized NP	70 ± 6	89 ± 3	163 ± 2	0.119 ± 0.002	−34.4 ± 2.5