In Vivo Evaluation of Complex Biogenic Silver Nanoparticle and Enoxaparin in Wound Healing

Figure 6

Longitudinal sections of dorsal skin after 21 days of thermal injury (HE 200x). (a) Contracture area with greater presence of extracellular matrix. Note the intense cellularity and large number of miofibroblasts in rats treated with free natrosol gel (). (b) HE staining after AgNP treatment reveals increases in dermis vascularity and lower amount of miofibroblast, since the higher amount was observed earlier. (c) Contracture region after Enox treatment showing hematoxylin-stained cells, typical of fibroblasts in hyperactive state in the papillary dermis (). (d) Treatment with AgNP-Enox showing a contracture area with reduced number of myofibroblasts and reduced leukocyte migration (). Images of rats after 28 days of treatment were not shown because there were similar to the rats treated for 21 days.

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