Ultra-Sensitive Colorimetric Plasmonic Sensing and Microfluidics for Biofluid Diagnostics Using Nanohole Array

Figure 10

Schematic overview of fabrication and integration of PDMS-based microfluidic device with nanohole array (NHA) sensor. (a) (Poly)dimethylsiloxane (PDMS) solution consisted of the base agent and the curing agent and is poured over a master mold. ((b)-(c)) The solution is cured thermally and, when cured, the PDMS device is excised and removed from the master mold. The PDMS-based microfluidic device can be integrated with the nanohole array sensor via (d) deposition of thin layer of SiO₂, (e) stamp of thin layer of adhesive (indicated by diagonal lines), and (f) compression between rigid plates. Note the deposited layers are not drawn to scale.

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