Research Article
Preparation and Evaluation of PEGylated and Folate-PEGylated Liposomes Containing Paclitaxel for Lymphatic Delivery
Table 1
Change of liposomal size and drug EE of PEGylated and folate-PEGylated liposomes containing Ptx various molar ratios of DSPE-mPEG#.
| Molar ratio of DSPE-mPEG | Liposomal size (nm) | Encapsulation efficiency (%) | PEGylated liposome | Folate-PEGylated liposome | PEGylated liposome | Folate-PEGylated liposome |
| 0 | 224 ± 21.8 | 224 ± 21.8 | 76 ± 1.8 | 76 ± 1.8 | 1 | 148 ± 3.65∗ | 140 ± 9.79∗ | 78 ± 3.6 | 77 ± 1.3 | 2 | 123 ± 10.2∗ | 126 ± 6.65∗ | 79 ± 2.7 | 82 ± 1.2∗ | 3 | 114 ± 6.81∗ | 122 ± 4.87∗ | 81 ± 2.3∗ | 88 ± 2.0∗ | 4 | 121 ± 20.0∗ | 125 ± 3.40∗ | 83 ± 4.8∗ | 68 ± 1.3∗ |
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Mean ± S.D. ( = 5). < 0.05 between 0 and specific molar ratio of DSPE-mPEG.
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