Preparation and Evaluation of PEGylated and Folate-PEGylated Liposomes Containing Paclitaxel for Lymphatic Delivery
Table 3
Pharmacokinetic parameters and targeting efficiencies of Ptx to mesenteric and axillary lymph nodes at 4 hours after i.v. administration (5 mg/kg) of the prepared PEGylated and folate-PEGylated liposomes containing Ptx and PADEXOL Inj. to rats#.
Parameters
PADEXOL Inj.
PEGylated liposome
Folate-PEGylated liposome
(hour)
3.43 ± 1.35
10.8 ± 3.51∗
9.14 ± 2.26∗
(mL/hr·kg)
1285 ± 317.0
413.5 ± 106.1∗
380.3 ± 115.7∗
(μg/mL)
5.16 ± 1.30
37.5 ± 7.47∗
51.4 ± 12.3∗
Concentration (ng/g lymph node)
Mesenteric lymph node
1364 ± 102.2
740.0 ± 236.1∗
810.4 ± 247.0∗
Axillary lymph node
1304 ± 112.7
672.8 ± 182.1∗
712.3 ± 102.4∗
Targeting efficiency
Mesenteric lymph node
8.06 ± 1.04
15.1 ± 4.14∗
18.8 ± 4.81∗
Axillary lymph node
8.01 ± 1.11
13.9 ± 2.98∗
16.6 ± 3.18∗
Mean ± S.D. ( = 5). < 0.05 between PADEXOL Inj. and the prepared liposomes.