Preparation and Evaluation of PEGylated and Folate-PEGylated Liposomes Containing Paclitaxel for Lymphatic Delivery

Table 3

Pharmacokinetic parameters and targeting efficiencies of Ptx to mesenteric and axillary lymph nodes at 4 hours after i.v. administration (5 mg/kg) of the prepared PEGylated and folate-PEGylated liposomes containing Ptx and PADEXOL Inj. to rats^#.

Parameters	PADEXOL Inj.	PEGylated liposome	Folate-PEGylated liposome
(hour)	3.43 ± 1.35	10.8 ± 3.51^∗	9.14 ± 2.26^∗
(mL/hr·kg)	1285 ± 317.0	413.5 ± 106.1^∗	380.3 ± 115.7^∗
(μg/mL)	5.16 ± 1.30	37.5 ± 7.47^∗	51.4 ± 12.3^∗
Concentration (ng/g lymph node)
Mesenteric lymph node	1364 ± 102.2	740.0 ± 236.1^∗	810.4 ± 247.0^∗
Axillary lymph node	1304 ± 112.7	672.8 ± 182.1^∗	712.3 ± 102.4^∗
Targeting efficiency
Mesenteric lymph node	8.06 ± 1.04	15.1 ± 4.14^∗	18.8 ± 4.81^∗
Axillary lymph node	8.01 ± 1.11	13.9 ± 2.98^∗	16.6 ± 3.18^∗

Mean ± S.D. ( = 5). < 0.05 between PADEXOL Inj. and the prepared liposomes.