Assaying Biomarkers via Real-Time Measurements of the Effective Relaxation Time of Biofunctionalized Magnetic Nanoparticles Associated with Biotargets

<div><svg height="13.1057pt" id="M120" style="vertical-align:-3.427799pt" version="1.1" viewbox="-0.0498162 -9.6779 40.8062 13.1057" width="40.8062pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0135,0,0,-0.0135,0,0)"><path d="M600 0V24L339 665L311 657L43 24V0H600ZM497 50H107L303 539L497 50Z" id="g113-133"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="641" vert-adv-y="641"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,8.678,0)"><path d="M471 456L444 459C426 433 414 430 388 430C324 430 270 434 216 434C103 434 51 374 23 338L43 317C96 366 146 380 221 375L154 109C149 86 147 68 147 52C147 4 168 -12 197 -12C240 -12 291 25 334 71L320 96C295 75 268 58 252 58C238 58 227 79 238 138C251 211 272 296 292 372C310 372 332 368 350 368C391 368 421 369 434 371C444 388 455 413 471 456Z" id="g113-241"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="483" vert-adv-y="483"></glyph.data></g><g transform="matrix(.0095,0,0,-0.0095,14.341,3.264)"><path d="M380 106C343 72 306 56 265 56C195 56 116 112 115 248C235 252 361 262 377 265C396 269 400 277 400 297C400 374 333 449 250 449H249C198 449 144 421 103 376S37 269 37 201C37 88 109 -12 232 -12C263 -12 332 6 395 84L380 106ZM225 412C281 412 315 364 314 312C314 297 308 292 290 292C232 290 176 289 120 289C135 370 180 412 225 412Z" id="g190-102"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="425" vert-adv-y="425"></glyph.data></g><g transform="matrix(.0095,0,0,-0.0095,18.372,3.264)"><path d="M99 437H52L25 408L28 397H99V104C99 38 91 32 32 26V0H246V25C185 32 178 38 178 104V397H365V104C365 38 358 32 303 25V0H526V25C451 32 444 37 444 104V397H555C565 404 568 428 563 437H444V471C443 562 453 609 466 629C476 647 492 661 518 661C551 661 581 639 600 620C609 611 619 612 629 620C637 626 647 636 650 644C654 654 654 666 645 677C627 697 597 710 564 712C521 707 476 686 432 642C412 664 374 688 316 690C269 685 230 668 190 636C139 596 120 551 111 525C104 505 99 477 99 449V437ZM365 437H178V461C178 537 192 580 209 605C223 627 245 648 283 648C336 648 374 615 394 585C384 566 378 550 374 533C369 516 365 488 365 456V437Z" id="g190-155"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="561" vert-adv-y="561"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,24.225,0)"><path d="M368 703H309L44 -163H104L368 703Z" id="g113-48"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="412" vert-adv-y="412"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,29.812,0)"><path d="M471 456L444 459C426 433 414 430 388 430C324 430 270 434 216 434C103 434 51 374 23 338L43 317C96 366 146 380 221 375L154 109C149 86 147 68 147 52C147 4 168 -12 197 -12C240 -12 291 25 334 71L320 96C295 75 268 58 252 58C238 58 227 79 238 138C251 211 272 296 292 372C310 372 332 368 350 368C391 368 421 369 434 371C444 388 455 413 471 456Z" id="g113-241"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="483" vert-adv-y="483"></glyph.data></g><g transform="matrix(.0095,0,0,-0.0095,35.476,3.264)"><path d="M245 635C92 635 37 457 37 312C37 149 91 -12 244 -12C395 -12 449 166 449 312C449 469 395 635 245 635ZM243 598C332 598 358 454 358 312C358 173 334 26 245 26C158 26 128 174 128 313S152 598 243 598Z" id="g50-49"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="487" vert-adv-y="487"></glyph.data></g></svg> as a function of the AFP concentration in a semilog plot. The solid line is the fitting curve to (<a href="https://static.hindawi.com/articles/jnm/volume-2015/497296/figures/#EEq4">4</a>).</div>

Journal of Nanomaterials

fig6

Figure 6

Figure 6: Assaying Biomarkers via Real-Time Measurements of the Effective Relaxation Time of Biofunctionalized Magnetic Nanoparticles Associated with Biotargets 

Figure 6 | Assaying Biomarkers via Real-Time Measurements of the Effective Relaxation Time of Biofunctionalized Magnetic Nanoparticles Associated with Biotargets 