Preparation of Cefquinome Nanoparticles by Using the Supercritical Antisolvent Process

Figure 1

The flowchart of preparing nanoparticles by supercritical fluid process. 1: gas cylinder; 2: valve; 3: purifier; 4: flowmeter; 5: refrigeration equipment; 6: high-pressure pump; 7: buffer tank; 8: valve; 9: high-pressure mixing vessel; 10: valve; 11: back pressure valve; 12: back pressure valve; 13: separation tank; 14: flowmeter; 15: crystallizer; 16: solution tank; 17: metering pump; 18: drain valve.