Research Article
Bioactive Glass Nanoparticles as a New Delivery System for Sustained 5-Fluorouracil Release: Characterization and Evaluation of Drug Release Mechanism
Table 1
The correlation coefficients (
) and release rate constants obtained by applying different mathematical models.
| | Mathematical models | Stage 1 (0–24 h) | Stage 2 (24 h–768 h) | | Correlation coefficient () | Release rate constant | Correlation coefficient () | Release rate constant |
| | Higuchi | 0.981 | = 51.8 × 10−3 h−0.5 | 0.969 | = 9.2 × 10−3 h−0.5 | | First-order | 0.955 | = 10.95 × 10−3 h−1 | 0.929 | = 0.41 × 10−3 h−1 | | Baker-Lonsdale | 0.998 | = 0.42 × 10−3 h−1 | 0.956 | = 0.04 × 10−3 h−1 | | Hixson-Crowell | 0.951 | = 3.5 × 10−3 h−1 | 0.923 | = 0.12 × 10−3 h−1 |
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