Radiosensitizing and Hyperthermic Properties of Hyaluronan Conjugated, Dextran-Coated Ferric Oxide Nanoparticles: Implications for Cancer Stem Cell Therapy

Figure 8

The apoptotic response of HA-DESPIONs in combination with hyperthermia in UT-SCC-14 cells. The normalized apoptotic index (relative to controls) is presented at three different temperatures for nanoparticles alone (black column), hyperthermia alone (gray column), and the combination of hyperthermia and nanoparticles (dark gray column). Nanoparticles combined with hyperthermia at 42°C showed significant growth in apoptotic cell death compared to any other combinations ().