Lipid Reconstitution-Enabled Formation of Gold Nanoparticle Clusters for Mimetic Cellular Membrane

Figure 1

Self-assembling gold nanoparticles with synthetic phospholipid membranes driving gold nanoparticle clustering. (a) Schematic image of the formation of lipid-coated AuCLs. (b) Reconstituted lipid membrane enveloping the surface of AuCLs is visualized in a transmission electron microscopy (TEM) image, which shows surface coverage of a phospholipid membrane surrounding the AuCL dimer with a thickness of 4~6 nm. Incubation of AuNPs with SUV allows encapsulation of AuCLs. (c) Types of phospholipids used in this study: molecular structures of POPC, POPS, and POPE.