Solid-State Nanopore-Based DNA Sequencing Technology

Figure 2

The electrical detection methods to sequence DNA molecule based on solid-state nanopores. (a) Basic principle of DNA sequencing via ionic blockade current signal [18]. (b) Schematic of tunnel-current detection method via a pair of nanoelectrodes fabricated at the edge of the nanopore [42]. Copyright © 2010, Nature Publishing Group. (c) Middle: schematic of MOS capacitive synthetic nanopore to detect DNA sequence. Right: A TEM image of the cross-section of the capacitor membrane structure. Left: A TEM micrograph of ~8 nm diameter pore drilled through the capacitor [48, 49]. Copyright © 2006, IOP Publishing.

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