Evaluation of Biomarkers of NAFLD in a Cohort of Morbidly Obese Patients
Figure 2
Histological assessment in NAFLD. NASH is histologically defined by increased steatosis, fibrosis, and lobular inflammation (a/b). Apoptosis is a key feature of NASH, which is accompanied by an increase in TUNEL positive cells (c/d). Hepatocyte apoptosis triggers HSC activation and thus fibrogenesis. Representative slides with quantification of collagen by Sirius red staining (e/f).
