Research Article

Microarray Analyses of Genes Differentially Expressed by Diet (Black Beans and Soy Flour) during Azoxymethane-Induced Colon Carcinogenesis in Rats

Table 2

Select genes significantly affected by carcinogen (AOM) treatment in the distal colonic epithelium of male F344 rats1.

Gene symbol Gene titleAOM (fold change)

(I) Extracellular matrix, cell adhesion, cytoskeleton

Fn1fibronectin 11.7
Col1a1collagen, type I, alpha 11.6
Vimvimentin1.5
Tmsb10thymosin, beta 101.3
Col3a1collagen, type III, alpha 11.3

(II) Immune, defense, inflammation, stress

Pla2g2aphospholipase A2, group IIA (platelets, synovial fluid)2.4
Cd74Cd74 molecule, major histocompatibility complex, class II invariant chain2.1
Lyz2lysozyme 22.1
RT1-Db1RT1 class II, locus Db12.0
RT1-DMbRT1 class II, locus DMb1.7
RatNP-3defensin RatNP-3 precursor1.7
RT1-Dahistocompatibility 2, class II antigen E alpha1.6
RT1-BaRT1 class II, locus Ba1.5
Cxcl13chemokine (C-X-C motif) ligand 131.5
RT1-BbRT1 class II, locus Bb1.5
Ccl2chemokine (C-C motif) ligand 21.4
Mifmacrophage migration inhibitory factor1.3
RT1-M3-1RT1 class Ib, locus M3, gene 11.3
Irf7interferon regulatory factor 71.3
Cxcr4chemokine (C-X-C motif) receptor 41.3
Il15interleukin 150.6

(III) Protein processing, synthesis, degradation

Rps7ribosomal protein S71.4
Rps15ribosomal protein S151.4
Pfdn2prefoldin subunit 21.4
Hspe1heat shock protein 1 (chaperonin 10)1.3
Rpl37ribosomal protein L371.3
Rpl4ribosomal protein L41.3
Psmb4proteasome (prosome, macropain) subunit, beta type 41.3
Rpl3lribosomal protein L3-like1.3
Rps4xribosomal protein S4, X-linked1.3
Rps17ribosomal protein S171.3
Rpl36alribosomal protein L36a-like1.3
Rps9ribosomal protein S91.3

1Data expressed as mean-fold change normalized to saline-injected animals ( 𝑛 = 1 2 /group). All genes presented were significantly altered compared to saline-injected animals ( 𝑃 < 0 . 0 5 ).