Table 2: Proinflammatory effects of n-6 fatty-acid-derived eicosanoids and anti-inflammatory effects of the n-3 fatty-acid-derived eicosanoids.

Proinflammatory effects of the n-6 fatty-acid-derived eicosanoids

Arachidonic acid (n-6) derived eicosanoidsPhysiological effectsOrgans or cells

ProstaglandinsPGD2Bronchoconstriction ProinflammatoryBronchi
Activation of eosinophils
PGE2Proarrhythmic
Induces fever
Causes pain
Increases production of IL-6
Vessels

Nociceptor sensory neurons
PGF2BronchoconstrictionBronchi
PGI2ProarrhythmicVessels
Causes painNociceptor sensory neurons

ThromboxanesTXA2Proaggregation
Vasoconstriction
Bronchoconstriction
Platelets
Vessels
Bronchi
TXB2Proaggregation
Vasoconstriction
Bronchoconstriction
Platelets
Vessels
Bronchi

LeukotrienesLTA4
LTB4Proinflammatory
Chemotaxis
Release of reactive oxygen species
Leukocytes
Leukocytes
Granulocytes
LTC4
LTD4
LTE4

Anti-inflammatory effects of the n-3 fatty-acid-derived eicosanoids

EPA and DHA (n-3) derived eicosanoidsPhysiological effectsOrgans or cells

ProstaglandinsPGD3
PGE3AntiarrhythmicVessels
PGF3
PGI3AntiarrhythmicVessels

ThromboxanesTXA3AntiaggregationPlatelets
TXB3AntiaggregationPlatelets

LeukotrienesLTA5
LTB5Anti-inflammatoryLeukocytes
LTC5
LTD5
LTE5

ResolvinsRVE1Antiaggregation Anti-inflammatoryPlatelets
Dendritic cells
RVDAnti-inflammatory

NeuroprotectinNPD1Anti-inflammatory Antiapoptotic
Decreases oxidative stress
Retina (photoreceptor cells) and brain

Data elaborated from [21, 3739].