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Journal of Nutrition and Metabolism
Volume 2012 (2012), Article ID 585170, 7 pages
http://dx.doi.org/10.1155/2012/585170
Clinical Study

Flaxseed Lignan Complex Administration in Older Human Type 2 Diabetics Manages Central Obesity and Prothrombosis—An Invitation to Further Investigation into Polypharmacy Reduction

1Department of Health Studies, Cape Breton University, P.O. Box 5300, Sydney, NS, Canada B1P 6L2
2Department of Biology, Cape Breton University, P.O. Box 5300, Sydney, NS, Canada B1P 6L2
3Department of Biology, Kwantlen Polytechnic University, 8771 Lansdowne Road, Richmond, BC, Canada V6X 3V8
4School of Nursing, Cape Breton University, P.O. Box 5300, Sydney, NS, Canada B1P 6L2
5Faculty of Medicine, Saint James School of Medicine, Bonaire, The Netherlands

Received 16 July 2012; Revised 6 September 2012; Accepted 6 September 2012

Academic Editor: Phillip B. Hylemon

Copyright © 2012 D. E. Barre et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aim. Animal and human study evidence supports the hypothesis that flaxseed lignan complex (FLC) at a dose of 600 mg secoisolariciresinol diglucoside (SDG)/day for three months would combat hyperglycaemia, dyslipidemia, blood pressure, central obesity, prothrombotic state, inflammation, and low density lipoprotein (LDL) oxidation. Methods. Sixteen type 2 diabetic patients completed this double-blind, randomised crossover placebo-controlled study. A univariate repeated measures analysis of covariance (significance ) was followed by a mixed linear model effects analysis corrected for multiple comparisons (MCC). Results. Prior to MCC, FLC caused decreased fasting plasma glucose, A1c, inflammation (c-reactive protein (CRP) and interleukin-6 (IL-6)), and increased bleeding time. After correction for multiple comparisons, FLC induced a statistically significant increase in bleeding time and smaller waist circumference gain. No treatment effect occurred in the other variables before or after adjustment. Conclusions. It is concluded that FLC significantly increased bleeding time thus reducing the prothrombotic state, reduced central obesity gain as measured by waist circumference, and did not affect significantly the other dependent variables measured after adjustment for multiple comparisons. These findings, not yet published in human type 2 diabetes, suggest that this FLC dose over at least three months, may, subject to further investigation, reduce polypharmacy.