Dietary Conjugated Linoleic Acid and Hepatic Steatosis: Species-Specific Effects on Liver and Adipose Lipid Metabolism and Gene Expression

Table 1

Studies showing that trans-10, cis-12 CLA induced significant (P < 0.05) increases or decreases, or where there was no change (P > 0.05) in body, adipose, and liver weights and liver lipid concentration.

Species	Change	Body weight	Adipose tissue	Liver weight	Liver lipids
Mice^1	Increase	—	—	24 (92)	19 (515)
	Decrease	21 (31)^2	29 (666)	—	—
	No change	16	—	2	2
Rats^3	Increase	—	—	—	1 (25)
	Decrease	—	1 (23)	—	4 (19)
	No change	11	3	8	4
Hamsters^4	Increase	—	—	8 (20)	—
	Decrease	2 (14)	11 (20)	—	3 (37)
	No change	11	2	2	5
Humans^5	Increase	—	—	—	—
	Decrease	2	6	—	—
	No change	11	13	—	—

¹Studies used: [22, 25, 27–48].
²Number of observations (mean percent change).
³Studies used: [49–53].
⁴Studies used: [54–62].
⁵Studies used: [63–81].