Effects of High Phosphorus Diet on Bone Metabolism-Related Gene Expression in Young and Aged Mice
Table 2
Body weight, serum Ca and P, serum PTH, and markers of bone turnover.
Young
Aged
Two-way ANOVA1
Control
High P
Control
High P
Initial body weight (g)
44.10 ± 0.79A
44.20 ± 0.65A
52.71 ± 2.17B
53.84 ± 2.56B
A
Final body weight (g)
48.66 ± 1.43
46.18 ± 0.67
51.47 ± 2.28
50.69 ± 2.19
Serum Ca (mg/dL)
9.15 ± 0.17
8.67 ± 0.20
8.81 ± 0.27
8.60 ± 0.12
Serum P (mg/dL)
9.23 ± 0.41
9.49 ± 0.47
9.07 ± 0.68
9.08 ± 0.60
Serum PTH (pg/mL)
52.8 ± 12.5A
181.4 ± 33.0B
76.7 ± 13.8A
306.1 ± 51.1C
P, A
Serum OC (ng/mL)
26.58 ± 0.83A
37.53 ± 2.94B
7.31 ± 0.48C
13.44 ± 0.78D
P, A
Urine CTx (g/mmol creatinine)
5.98 ± 0.91A
16.73 ± 1.22B
5.62 ± 1.02A
9.61 ± 1.13C
P, A, P × A
The data indicate the mean ± SEM of 6 mice. The different superscript letters denote significant differences ().
1Significant effect (): P = effect of high P diet; A = effect of age; P × A = effect of interaction.