Hepatoprotective Activity of Herbal Composition SAL, a Standardize Blend Comprised of Schisandra chinensis, Artemisia capillaris, and Aloe barbadensis

Table 2

Unexpected synergistic effect of Schisandra chinensis, Artemisia capillaris, and N-931 in liver protection.

Composition	Material	Dose (mg/kg)		Percent inhibition of vehicle
				APAP (400 mg/kg)	CCL4 (25 L/kg)
SAL	Schisandra (L498) ()	106.7	10	18.4	17.5
	Artemisia (R684) ()	213.3	10	20.8	22.8
	Aloe (N-931) ()	80.0	10	20.8	15.0
	Expected	400	—	48.8	45.9
	Observed	400	10	52.8	46.3

Data of serum ALT are presented as percentage change of vehicle. Mice () were given composition SAL (400 mg/kg), Schisandra (106.7 mg/kg), Artemisia (213.3 mg/kg), N-931 (80 mg/kg), and vehicle at −48 hr, −24 hr, and −2 hr and +6 hr after induction of model suspended in 10% Tween-20. Calculated value according to Colby’s equation = ; that is, , , and .  ata observed when a composition was orally administered at 400 mg/kg, when observed ≥ expected = unexpected synergy.