Omega-3 Fatty Acids: Possible Neuroprotective Mechanisms in the Model of Global Ischemia in Rats

Figure 3

Evaluation of 3 treatments at the doses of 5 and 10 mg/kg on the striatal contents of DA (a), DOPAC (b), and NE (c), in rats subjected to brain ischemia and reperfusion for 7 days. The numbers of animals per group were the following: for DA, SO = 14, ISC = 9, ISC + ω3 (5) = 19, and ISC + ω3 (10) = 15; for DOPAC, SO = 14, ISC = 11, ISC + ω3 (5) = 15, and ISC + ω3 (10) = 14; for NE, SO = 8, ISC = 10, ISC + ω3 (5) = 8, and ISC + ω3 (10) = 6. The columns represent means ± SEM and the groups are sham-operated (SO); ischemic (ISC) untreated; and ischemic after 3 treatments for 7 days. DA: (A) versus SO, q = ; (B) versus 3 (5), q = ; (C) versus 3 (10), q = . DOPAC: (A) versus SO, t = 2.484, df = 23; (B) versus 3 (5), q = ; (C) versus 3 (10), t = 2.085, df = 23. NE: (A) versus SO, q = ; (B) versus 3 (2.5), q = ; (C) versus 3 (5), q = (one-way ANOVA and Newman-Keuls test as the post hoc test).

(a)

(b)

(c)