Evaluation of Aromatic Boronic Acids as Ligands for Measuring Diabetes Markers on Carbon Nanotube Field-Effect Transistors

Table 1

Summary of the binding studies performed with the aromatic boronic acids on the CNT-FET wafers. The studies were performed as described in the text and represent the average of at least 2 titration curves for each boronic acid. Each titration curve represents at least 5 concentration points of the boronic acids with each point measured in quadruplicate.

Boronic acids	Optimal coating concentration	Peak impedance value of gHSA^∗
Phenyl boronic acid	70 mM (±6.2 mM)	12.5% (±5.4%)
Naphthalene boronic acid	41 mM (±4.8 mM)	10.6% (±3.2%)
Phenanthrene boronic acid	14 mM (±7 mM)	12.2% (±2.8%)
Pyrene boronic acid	2 mM (±1.2 mM)	13.2% (±4.2%)

^∗Impedance increases were assessed at the optimal coating concentrations for each boronic acid and represent the percent increase in the impedance compared to baseline.