Tipping the Proteome with Gene-Based Vaccines: Weighing in on the Role of Nanomaterials

Figure 2

Graphical representation of the formation of complexes between gold nanoparticles, protamine, and siRNA. The cationic protamine condenses the RNA into nanoparticles, assisting its stabilization and protecting it from degradation. The protamine: RNA complexes then bind to the surface of the gold nanoparticle, which confers more stability and protection.