- About this Journal ·
- Abstracting and Indexing ·
- Advance Access ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Journal of Nanotechnology
Volume 2013 (2013), Article ID 768724, 8 pages
Amino-Functionalized Silica Nanoparticles: In Vitro Evaluation for Targeted Delivery and Therapy of Pancreatic Cancer
Pharmaceutical Research Institute at Albany College of Pharmacy and Health Sciences, 1 Discovery Drive, Rensselaer, NY 12144, USA
Received 14 August 2012; Accepted 5 December 2012
Academic Editor: Thomas Thundat
Copyright © 2013 Abbey Y. Kardys et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- American Cancer Society, Cancer Facts & Figures 2012, pp. 19, http://www.cancer.org/Research/CancerFactsFigures/CancerFactsFigures/cancer-facts-figures-2012.
- R. T. Greenlee, M. B. Hill-Harmon, T. Murray, and M. Thun, “Cancer statistics, 2001,” A Cancer Journal for Clinicians, vol. 51, no. 1, pp. 15–36, 2001.
- T. P. Yeo, R. H. Hruban, S. D. Leach et al., “Pancreatic cancer,” Current Problems in Cancer, vol. 26, no. 4, pp. 176–275, 2002.
- R. H. Hruban, G. M. Petersen, M. Goggins et al., “Familial pancreatic cancer,” Annals of Oncology, vol. 10, supplement 4, pp. 69–73, 1999.
- G. M. Petersen and R. H. Hruban, “Familial pancreatic cancer: where are we in 2003?” Journal of the National Cancer Institute, vol. 95, no. 3, pp. 180–181, 2003.
- D. F. Emerich and C. G. Thanos, “Nanotechnology and medicine,” Expert Opinion on Biological Therapy, vol. 3, no. 4, pp. 655–663, 2003.
- T. Kubik, K. Bogunia-Kubik, and M. Sugisaka, “Nanotechnology on duty in medical applications,” Current Pharmaceutical Biotechnology, vol. 6, no. 1, pp. 17–33, 2005.
- S. E. Leucuta, “Nanotechnology for delivery of drugs and biomedical applications,” Current Clinical Pharmacology, vol. 5, no. 4, pp. 257–280, 2010.
- D. J. Bharali and S. A. Mousa, “Emerging nanomedicines for early cancer detection and improved treatment: current perspective and future promise,” Pharmacology & Therapeutics, vol. 128, no. 2, pp. 324–335, 2010.
- M. Ferrari, “Cancer nanotechnology: opportunities and challenges,” Nature Reviews Cancer, vol. 5, no. 3, pp. 161–171, 2005.
- S. Nie, Y. Xing, G. J. Kim, and J. W. Simons, “Nanotechnology applications in cancer,” Annual Review of Biomedical Engineering, vol. 9, pp. 257–288, 2007.
- S. Singhal, S. Nie, and M. D. Wang, “Nanotechnology applications in surgical oncology,” Annual Review of Medicine, vol. 61, pp. 359–373, 2010.
- G. S. Kwon, “Polymeric micelles for delivery of poorly water-soluble compounds,” Critical Reviews in Therapeutic Drug Carrier Systems, vol. 20, no. 5, pp. 357–403, 2003.
- C. M. Walko and H. McLeod, “Pharmacogenomic progress in individualized dosing of key drugs for cancer patients,” Nature Clinical Practice Oncology, vol. 6, no. 3, pp. 153–162, 2009.
- I. Brigger, C. Dubernet, and P. Couvreur, “Nanoparticles in cancer therapy and diagnosis,” Advanced Drug Delivery Reviews, vol. 54, no. 5, pp. 631–651, 2002.
- J. Lu, M. Liong, J. I. Zink, and F. Tamanoi, “Mesoporous silica nanoparticles as a delivery system for hydrophobic anticancer drugs,” Small, vol. 3, no. 8, pp. 1341–1346, 2007.
- T. Y. Ohulchanskyy, I. Roy, L. N. Goswami et al., “Organically modified silica nanoparticles with covalently incorporated photosensitizer for photodynamic therapy of cancer,” Nano Letters, vol. 7, no. 9, pp. 2835–2842, 2007.
- R. Kumar, I. Roy, T. Y. Ohulchanskyy et al., “Covalently dye-linked, surface-controlled, and bioconjugated organically modified silica nanoparticles as targeted probes for optical imaging,” ACS Nano, vol. 2, no. 3, pp. 449–456, 2008.
- H. Yan, C. Teh, S. Sreejith, L. Zhu, A. Kwok, W. Fang, et al., “Functional mesoporous silica nanoparticles for photothermal-controlled drug delivery in vivo,” Angewandte Chemie, vol. 51, no. 33, pp. 8373–8377, 2012.
- M. Gary-Bobo, Y. Mir, C. Rouxel, D. Brevet, O. Hocine, M. Maynadier, et al., “Multifunctionalized mesoporous silica nanoparticles for the in vitro treatment of retinoblastoma: drug delivery, one and two-photon photodynamic therapy,” International Journal of Pharmaceutics, vol. 432, no. 1-2, pp. 99–104, 2012.
- I. Roy, T. Y. Ohulchanskyy, H. E. Pudavar et al., “Ceramic-based nanoparticles entrapping water-insoluble photosensitizing anticancer drugs: a novel drug-carrier system for photodynamic therapy,” Journal of the American Chemical Society, vol. 125, no. 26, pp. 7860–7865, 2003.
- P. Sharma, N. E. Bengtsson, G. A. Walter, H. B. Sohn, G. Zhou, N. Iwakuma, et al., “Gadolinium-doped silica nanoparticles encapsulating indocyanine green for near infrared and magnetic resonance imaging,” Small, vol. 8, no. 18, pp. 2856–2868, 2012.
- P. Wang, X. Hu, S. Cook, and H. M. Hwang, “Influence of silica-derived nano-supporters on cellobiase after immobilization,” Applied Biochemistry and Biotechnology, vol. 158, no. 1, pp. 88–96, 2009.
- D. J. Bharali, I. Klejbor, E. K. Stachowiak et al., “Organically modified silica nanoparticles: a nonviral vector for in vivo gene delivery and expression in the brain,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 32, pp. 11539–11544, 2005.
- D. Luo and W. M. Saltzman, “Enhancement of transfection by physical concentration of DNA at the cell surface,” Nature Biotechnology, vol. 18, no. 8, pp. 893–895, 2000.
- W. Tan, K. Wang, X. He et al., “Bionanotechnology based on silica nanoparticles,” Medicinal Research Reviews, vol. 24, no. 5, pp. 621–638, 2004.
- S. Santra, P. Zhang, K. Wang, R. Tapec, and W. Tan, “Conjugation of biomolecules with luminophore-doped silica nanoparticles for photostable biomarkers,” Analytical Chemistry, vol. 73, no. 20, pp. 4988–4993, 2001.
- L. M. Rossi, L. Shi, F. H. Quina, and Z. Rosenzweig, “Stober synthesis of monodispersed luminescent silica nanoparticles for bioanalytical assays,” Langmuir, vol. 21, no. 10, pp. 4277–4280, 2005.
- H. Flachsbart and W. Stöber, “Preparation of radioactively labeled monodisperse silica spheres of colloidal size,” Journal of Colloid and Interface Science, vol. 30, no. 4, pp. 568–573, 1969.
- K. Stalder and W. Stober, “Haemolytic activity of suspensions of different silica modifications and inert dusts,” Nature, vol. 207, no. 999, pp. 874–875, 1965.
- D. J. Bharali, V. Pradhan, G. Elkin et al., “Novel nanoparticles for the delivery of recombinant hepatitis B vaccine,” Nanomedicine, vol. 4, no. 4, pp. 311–317, 2008.
- H. Meng, M. Liong, T. Xia et al., “Engineered design of mesoporous silica nanoparticles to deliver doxorubicin and P-glycoprotein siRNA to overcome drug resistance in a cancer cell line,” ACS Nano, vol. 4, no. 8, pp. 4539–4550, 2010.
- P. Michl, M. Buchholz, M. Rolke et al., “Claudin-4: a new target for pancreatic cancer treatment using Clostridium perfringens enterotoxin,” Gastroenterology, vol. 121, no. 3, pp. 678–684, 2001.
- C. A. Foss, J. J. Fox, G. Feldmann et al., “Radiolabeled anti-claudin 4 and anti-prostate stem cell antigen: initial imaging in experimental models of pancreatic cancer,” Molecular Imaging, vol. 6, no. 2, pp. 131–139, 2007.
- H. Yamaguchi, T. Kojima, T. Ito, D. Kyuno, Y. Kimura, M. Imamura, et al., “Effects of Clostridium perfringens enterotoxin via claudin-4 on normal human pancreatic duct epithelial cells and cancer cells,” Cellular & Molecular Biology Letters, vol. 16, no. 3, pp. 385–397, 2011.