Intestinal Lymphatic Delivery of Praziquantel by Solid Lipid Nanoparticles: Formulation Design, In Vitro and In Vivo Studies

Table 1

Effect of different process parameters on particle size (PS), polydispersity index (PI), and zeta potential (ZP).

Process variables	PS (nm)	PI	ZP (−mV)
Homogenization time (HT)
2.5 min	146.7±2.59	0.463±0.027	10.1±0.29
5 min	132.3±1.43	0.289±0.024	9.8±0.38
10 min	121.6±1.58	0.213±0.012	9.9±0.45
15 min	129.2±1.72	0.392±0.019	9.8±0.52
Sonication time (ST)
2.5 min	421.1±7.69	0.631±0.034	9.7±0.49
5 min	218.7±7.14	0.512±0.031	9.6±0.42
10 min	133.4±1.73	0.404±0.039	9.7±0.38
15 min	130.3±1.82	0.293±0.044	9.7±0.47
Volume of formulation (VF)
50 mL	127.4±1.75	0.289±0.037	9.6±0.42
100 mL	132.4±1.32	0.314±0.038	9.7±0.38
200 mL	134.2±1.58	0.396±0.042	9.7±0.47