Table 1: Effect of different process parameters on particle size (PS), polydispersity index (PI), and zeta potential (ZP).

Process variablesPS (nm)PIZP (−mV)

Homogenization time (HT)
 2.5 min
 5 min
 10 min
 15 min

Sonication time (ST)
 2.5 min
 5 min
 10 min
 15 min

Volume of formulation (VF)
 50 mL
 100 mL
 200 mL