Intestinal Lymphatic Delivery of Praziquantel by Solid Lipid Nanoparticles: Formulation Design, In Vitro and In Vivo Studies

Table 3

(a) Particle size and entrapment efficiency of the PZQ-loaded SLN after storage at refrigerated temperature (4±1°C) and at 25±1°C/65±5% RH (values are reported as mean ± SD, 𝑛=4). (b) Particle size and entrapment efficiency of the PZQ-loaded SLN after storage at different pH conditions (values are reported as mean ± SD, 𝑛=4).

(a)

Formulations	Particle size (nm)			Entrapment efficiency (%)
	Initially (0 hr)	After 6 months		Initially (0 hr)	After 6 months
	RT	4±1 °C	25±1 °C/65±5% RH	RT	4±1 °C	25±1 °C/65±5% RH
TP-SLN (F25)	123.1±3.41	128.1±4.72	139.3±3.82	86.6±0.94	82.6±0.29	83.9±0.14
TS-SLN (F26)	132.6±4.29	140.2±5.11	153.6±4.74	84.6±0.81	79.3±0.47	78.6±0.43

(b)

Formulations	Particle size (nm)			Entrapment efficiency (%)
	Initially (0 hr)	pH 1.2 (2 hr)	pH 7.5 (6 hr)	Initially (0 hr)	pH 1.2 (2 hr)	pH 7.5 (6 hr)
TP-SLN (F25)	123.1±3.41	348.4±6.93	169.2±3.62	86.6±0.94	34.4±0.81	77.3±0.89
TS-SLN (F26)	132.6±4.29	364.6±7.46	184.6±3.49	84.6±0.81	36.1±0.72	74.5±0.95