Table 5: Pharmacokinetic parameters for praziquantel in rats after intraduodenal administration of PZQ-SLNs at an equivalent praziquantel dose of 50 mg/kg to rats treated with cycloheximide (CHM) and saline, respectively (values are means SD, ).

Formulation (h) (μg/mL) (μg h/mL)MRT (h) (h)

PZQ-SLN + CHM0.5 2.39
PZQ-SLN + Saline0.33 6.28