Organic Nanovesicular Cargoes for Sustained Drug Delivery: Synthesis, Vesicle Formation, Controlling “Pearling” States, and Terfenadine Loading/Release Studies

Table 1

Results of zebrafish embryo toxicity study with toxicological indices and major organs/systems affected in positive control and at MTC in test compounds (—: no effect, x: slightly toxic, xx: moderately toxic, and xxx: severely toxic).

	Tested compound (1)	Phenobarbital
Test concentrations (M)	0.03, 0.1, 0.3, 1, 3, 10, 30	3000
Statistically significant toxic concentration (M)	—	Positive Control
No observed adverse; effect level (NOAEL) (M)	30
Minimal toxic concentration (MTC) (M)	—
Parameters of toxicity at MTC
Body shape	x	xxx
Somites	—	xxx
Notochord	—	xxx
Tail	—	xxx
Fins	—	xxx
Brain	—	xxx
Upper jaw	—	xxx
Heart	—	xx
Intestine	x	xxx
Lower jaw	—	xx
Liver	—	xxx
Swim bladder	x	xxx