Methotrexate Increases Skeletal Muscle GLUT4 Expression and Improves Metabolic Control in Experimental Diabetes
Table 1
Nonfasting glucose and insulin serum levels in genetically diabetic female C57BL/KsJ-mice () and their normal littermates () at baseline and after 4 weeks of treatment with methotrexate (MTX) or vehicle.
Vehicle
MTX
Vehicle
MTX
Body weight (gr)
Baseline
26 ± 4
27 ± 4
40 ± 7
42 ± 6
After treatment
28 ± 5
26 ± 5
43 ± 5
39 ± 5
Glucose (mg/dL)
Baseline
185 ± 9
178 ± 10
543 ± 28
521 ± 19
After treatment
177 ± 11
155 ± 8*
499 ± 26
293 ± 15#
Insulin (pmol/L)
Baseline
68 ± 12
75 ± 7
165 ± 18
171 ± 14
After treatment
64 ± 9
60 ± 6
159 ± 15
112 ± 11#
HOMAIR (mmol/L*UI/L)
Baseline
5.18 ± 0.92
5.49 ± 0.53
36.87 ± 3.9
36.66 ± 4.2
After treatment
4.66 ± 0.64
3.83 ± 0.52#
32.65 ± 4.8
13.51 ± 2.2#
Data are means ± SD. Only significant P are presented. *P < 0.05 versus baseline; #P < 0.001 versus baseline.