Review Article

Exercise Intensity Modulation of Hepatic Lipid Metabolism

Table 1

Effects of Exercise Intensity on Hepatic Lipid Metabolism in Animal Models and Human.

ReferenceSampleIntensityDurationResults

Mondon et al. [22]Rat malesModerate intensity 60% VO2max12 weeks Reduction TG, FFA levels, VLDL-TG secretion was 50% lower in exercise trained rats
Stein et al. [17]Untrained men65%, 75% and 85% maximal heart rate12 weeksIncreases in the HDL cholesterol fractions in the 75% and 85% groups. Significant decreases in LDL fractions in the 75% group
Wallace et al. [23]Trained menModerate (73% of 1 RM) and High intensity (92% 1 RM)Acute 90 minIncreases HDL-c and its subfractions (HDL2 and HDL3) in moderate when compared to high intensity strength exercise
Aellen et al. [2]Untrained men 16 trained intensity above and 17 below the anaerobic threshold9 weeksIncreases in the HDL and HDL2 cholesterol fractions in the below the anaerobic threshold
Lira et al. [11]Rat malesModerate intensity 60% VO2max8 weeksExercised rats showed reduction of TG, VLDL-TG levels, hepatic tissue TAG content, and lower rate of hepatic VLDL secretion, gene expression of apoB and MTP when compared with control rats
Magkos et al. [15]Untrained men80% of peak torque productionAcute 90 minResistance exercise lowered fasting plasma VLDL-TG, increased VLDL-TG plasma clearance rate, and shortened the mean residence time of VLDL-TG in the circulation
Tsekouras et al. [19]Untrained men60 and 90% of VO2peak8 weeksHigh-intensity interval training VLDL-TG concentration was reduced, and this was due to reduced hepatic VLDL-TG secretion rate
Tsekouras et al. [24]Untrained men80% of peak torque productionAcute 90 minReduced VLDL-TAG concentrations, plasma clearance rate of VLDL-TAG was significantly higher after exercise than rest, and the mean residence time of VLDL-TG in the circulation was significantly shorter. Fasting plasma NEFA and serum beta-hydroxybutyrate concentrations were both significantly higher after exercise than rest
Chapados et al. [12]Rat malesModerate intensity 60% VO2max8 weeksReduction in liver TG content, reduces VLDL synthesis and/or secretion in fed rats probably via MTP regulation
Lira et al. [14]Trained men90% VO2maxAcute ~8 minTotal cholesterol and LDL cholesterol were reduced after the exhaustion and 1 h recovery periods when compared with rest periods
Lira et al. [25]Untrained men50%, 75%, 90% and 110%-1 RMAcute ~10 minThe 75%-1 RM group demonstrated TG reduction when compared to other groups. HDL-c concentration was significantly greater after resistance exercise in 50%-1 RM and 75%-1 RM when compared to 110%-1 RM group
Lira et al. [21]Trained men115% VO2maxAcute ~4 minThere were no significant changes in the lipid profile

VO2max: maximal oxygen consumption. 1 RM: one repetition maximal. TG: triglycerides. FFA: free fatty acid. VLDL-TG: very low density lipoprotein. NEFA: non-esterified fatty acids. LDL: low density lipoprotein. HDL: high density lipoprotein. MTP: microsomal transfer protein. apoB: apolipoprotein B.