Research Article
Stat3 Expression and Its Correlation with Proliferation and Apoptosis/Autophagy in Gliomas
Table 4
Correlation of EGFR amplification,
EGFRwt and EGFRvIII immunopositivity with pAkt
and pStat3 immunohistochemistry.
| | Activated pathway | EGFR amplification | P value |
| | Positive () | Negative () | |
| | Akt IHC | 3 (25.0%) | 8 (36.4%) | ns | | Akt WB* | 5 (41.7%) | 9 (41%) | ns | | Stat3 | 6 (50.0%) | 8 (31.8%) | ns |
| | EGFRwt (B + C) Immunohistochemistry |
| | Positive () | Negative () | |
| | Akt IHC | 7 (31.8%) | 4 (33.3%) | ns | | Akt WB* | 12 (67%) | 2 (12%) | .010 | | Stat3 | 9 (40.90%) | 5 (41.6%) | ns |
| | EGFRvIII (B + C) Immunohistochemistry |
| | Positive () | Negative () | |
| | Akt IHC | 3 (33.3%) | 8 (32.0%) | ns | | Akt WB* | 3 (33%) | 11 (44%) | ns | | Stat3 | 5 (55.5%) | 9 (36.0%) | ns |
|
|
ns = not significative.
*Only WB values >0.4 were considered.
|
