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Table 4: RTOG acute and late toxicities of radiation.

Parameters Preoperative EBRT group Postoperative EBRT group P value Acute (90 days) GI Grade 1-2 16 (84%) 11 (92%) .70 Grade 3-4 1 (5%) 0 (0%) GU Grade 1-2 0 (0%) 3 (25%) .05 Grade 3-4 0 (0%) 0 (0%) Wound complications Grade 1-2 0 (0%) 1 (8%) .39 Grade 3-4 0 (0%) 0 (0%) Infection Grade 1-2 0 (0%) 0 (0%) 1.00 Grade 3-4 1 (5%) 0 (0%) Skin Grade 1-2 2 (11%) 1 (8%) 1.00 Grade 3-4 0 (0%) 0 (0%) Pain Grade 1-2 11 (58%) 5 (42%) .47 Grade 3-4 0 (0%) 0 (0%) Neurologic Grade 1-2 2 (11%) 0 (0%) .51 Grade 3-4 0 (0%) 0 (0%) Gynecologic Grade 1-2 0 (0%) 0 (0%) 1.00 Grade 3-4 1 (5%) 0 (0%) Late (90 days) GI Grade 1-2 1 (5%) 2 (17%) .51 Grade 3-4 3 (16%) 3 (25%) GU Grade 1-2 0 (0%) 0 (0%) 1.00 Grade 3-4 1 (5%) 0 (0%) Wound complications Grade 1-2 0 (0%) 0 (0%) 1.00 Grade 3-4 1 (5%) 0 (0%) Infection Grade 1-2 0 (0%) 0 (0%) .31 Grade 3-4 4 (21%) 2 (17%) Skin Grade 1-2 0 (0%) 0 (0%) NS Grade 3-4 0 (0%) 0 (0%) Pain Grade 1-2 1 (5%) 0 (0%) 1.00 Grade 3-4 0 (0%) 0 (0%) Neurologic Grade 1-2 1 (5%) 0 (0%) 1.00 Grade 3-4 0 (0%) 0 (0%) Gynecologic Grade 1-2 0 (0%) 0 (0%) 1.00 Grade 3-4 2 (11%) 1 (8%) Lymphedema Grade 1-2 1 (5%) 0 (0%) 1.00 Grade 3-4 0 (0%) 0 (0%)

RTOG = Radiation therapy oncology group; EBRT = external beam radiation therapy; GI = gastrointestinal; GU = genitourinary.