Cell Cycle Regulating Kinase Cdk4 as a Potential Target for Tumor Cell Treatment and Tumor Imaging

Table 2

Percentage of cells in G1 phase after 24 hours of treatment with different concentrations of CKIA or CKIB (values are means ± standard deviations in %, 𝑛≥8, ^∗𝑃<.05, compared to control (0 𝜇M), resp.).

CKIA/𝜇M	0	0.05	0.1	0.5	1.0
HT-29	45.6 ± 4.1	62.3 ± 4.0*	68.1 ± 4.1*	90.1 ± 1.4*	89.9 ± 0.8*
FaDu	46.4 ± 4.7	55.7 ± 6.5*	56.9 ± 6.5*	82.2 ± 2.5*	84.5 ± 3.1*
THP-1	58.8 ± 4.5	87.3 ± 8.0*	92.1 ± 3.2*	86.2 ± 5.2*	61.7 ± 6.4
THP-1 macrophage	46.9 ± 5.9	45.1 ± 1.8*	51.9 ± 3.3	45.3 ± 1.5*	41.4 ± 2.0*
CKIB/𝜇M	0	0.05	0.1	0.5	1.0
HT-29	46.7 ± 2.4	54.0 ± 1.5*	58.7 ± 2.7*	81.5 ± 4.9*	89.9 ± 4.3*
FaDu	58.6 ± 3.4	64.7 ± 3.5*	65.8 ± 5.4*	69.4 ± 6.1*	70.7 ± 3.6*
THP-1	59.9 ± 1.8	68.6 ± 2.8*	73.5 ± 1.0*	86.8 ± 1.7*	89.1 ± 1.0*
THP-1 macrophage	52.2 ± 3.2	53.2 ± 2.4	53.6 ± 2.0	55.4 ± 2.0	54.6 ± 2.7