Biochanin A Modulates Cell Viability, Invasion, and Growth Promoting Signaling Pathways in HER-2-Positive Breast Cancer Cells

<table>Pathways inhibited by biochanin A in HER-2+ SK-BR-3 breast cancer cells. The protein expression data indicate that biochanin A treatment inhibits growth (p-HER-2, p-Erk), survival (Akt, mTOR, and NF<svg height="7.9499998" id="M143" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 8.7375002 7.9499998" width="8.7375002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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q-12 -27 -36 -158q-44 -7 -77 -15l-5 7l82 349q6 25 -2 25q-16 0 -72 -41l-14 22q44 41 89 69.5t66 28.5q19 0 19 -32q0 -16 -6 -43l-35 -160l146 143q94 92 136 92q20 0 33 -12t13 -30z" id="x1D705"></path></g>
</svg>B), and invasion (MMP-9 and MMP-14) promoting pathways in SK-BR-3 cells.</table>

Journal of Oncology

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Figure 9

Figure 9: Biochanin A Modulates Cell Viability, Invasion, and Growth Promoting Signaling Pathways in HER-2-Positive Breast Cancer Cells 