Table 3: Nuclear receptor target genes playing pivotal roles in diverse biological processes and cellular homeostasis were described to be differentially expressed in head and neck cancer.

NRTarget geneFunctionReference - target geneReference - head and neck

PPARG0S2Cell cycle Zandbergen et al. Biochem J 2005 Tokumaru et al. Cancer Res 2004
PDK1Energy homeostasisDegenhardt et al. J Mol Biol 2007 Wigfield et al. Br J Cancer 2008

RARp21WAF1/CIP1Cell cycle Liu et al. J Biol Chem 1996 Kapranos et al. Anticancer Res 2001
BIRC5/survivingApoptosis Pratt et al. J Cell Biochem 2003 Engels et al. J Pathol 2007
C/EBPεTranscription factor Schwarz et al. Mol Cell Biol 1997 Bennett et al. Cancer Res 2007
CRABPCarrier protein Nezzar et al. Mol Vis 2007 Won et al. Metabolism 2004
cyclins, CDKCell cycle Bour et al. Trends Cell Biol 2007Jeannon et al. Clin Otolaryngol Allied Sci 1998

ERc-MycTranscription factorMarkaverich et al. Steroids 2006 Pries et al. Int J Mol Med 2008
CyclinsCell cycle Eeckhoute et al. Genes Dev 2006 Nakashima et al. Eur Arch Otorhinolaryngol 2005 Lotayef et al. Br J Cancer 2000
CRABPCarrier protein Li et al. J Biol Chem 2003Vo et al. Anticancer Res 1998
CXCl12/SDF-1Chemokine/ligand Hall et al. Mol Endocrinol 2003 Rehman et al. J Biol Chem 2008
cathepsin DProteaseBretschneider et al. Mol Oncol 2008 Strojan et al. Anticancer Res 2000