- About this Journal ·
- Abstracting and Indexing ·
- Advance Access ·
- Aims and Scope ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Journal of Oncology
Volume 2009 (2009), Article ID 408038, 8 pages
Synergistic Induction of Apoptosis in Primary B-CLL Cells after Treatment with Recombinant Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand and Histone Deacetylase Inhibitors
Department of Urology and Interdisciplinary Graduate Program in Immunology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
Received 8 September 2008; Revised 6 February 2009; Accepted 10 April 2009
Academic Editor: Michael A. Carducci
Copyright © 2009 Lyse A. Norian et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- T. S. Griffith and D. H. Lynch, “TRAIL: a molecule with multiple receptors and control mechanisms,” Current Opinion in Immunology, vol. 10, no. 5, pp. 559–563, 1998.
- S. R. Wiley, K. Schooley, P. J. Smolak, et al., “Identification and characterization of a new member of the TNF family that induces apoptosis,” Immunity, vol. 3, no. 6, pp. 673–682, 1995.
- S. K. Kelley and A. Ashkenazi, “Targeting death receptors in cancer with Apo2L/TRAIL,” Current Opinion in Pharmacology, vol. 4, no. 4, pp. 333–339, 2004.
- G. Pan, K. O'Rourke, A. M. Chinnaiyan, et al., “The receptor for the cytotoxic ligand TRAIL,” Science, vol. 276, no. 5309, pp. 111–113, 1997.
- G. Pan, J. Ni, Y.-F. Wei, G.-I. Yu, R. Gentz, and V. M. Dixit, “An antagonist decoy receptor and a death domain-containing receptor for TRAIL,” Science, vol. 277, no. 5327, pp. 815–818, 1997.
- J. P. Sheridan, S. A. Marsters, R. M. Pitti, et al., “Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors,” Science, vol. 277, no. 5327, pp. 818–821, 1997.
- H. Walczak, M. A. Degli-Esposti, R. S. Johnson, et al., “TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL,” The EMBO Journal, vol. 16, no. 17, pp. 5386–5397, 1997.
- A. M. Chinnaiyan, C. G. Tepper, M. F. Seldin, et al., “FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis,” The Journal of Biological Chemistry, vol. 271, no. 9, pp. 4961–4965, 1996.
- J.-L. Bodmer, N. Holler, S. Reynard, et al., “TRAIL receptor-2 signals apoptosis through FADD and caspase-8,” Nature Cell Biology, vol. 2, no. 4, pp. 241–243, 2000.
- F. C. Kischkel, D. A. Lawrence, A. Chuntharapai, P. Schow, K. J. Kim, and A. Ashkenazi, “Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5,” Immunity, vol. 12, no. 6, pp. 611–620, 2000.
- J. C. Reed, “Mechanisms of apoptosis,” The American Journal of Pathology, vol. 157, no. 5, pp. 1415–1430, 2000.
- M. R. Sprick, M. A. Weigand, E. Rieser, et al., “FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2,” Immunity, vol. 12, no. 6, pp. 599–609, 2000.
- K. M. Hajra and J. R. Liu, “Apoptosome dysfunction in human cancer,” Apoptosis, vol. 9, no. 6, pp. 691–704, 2004.
- C. R. Johnson and W. D. Jarvis, “Caspase-9 regulation: an update,” Apoptosis, vol. 9, no. 4, pp. 423–427, 2004.
- A. Ashkenazi, P. Holland, and S. G. Eckhardt, “Ligand-based targeting of apoptosis in cancer: the potential of recombinant human apoptosis ligand 2/tumor necrosis factor-related apoptosis-inducing ligand (rhApo2L/TRAIL),” Journal of Clinical Oncology, vol. 26, no. 21, pp. 3621–3630, 2008.
- H. N. LeBlanc and A. Ashkenazi, “Apo2L/TRAIL and its death and decoy receptors,” Cell Death and Differentiation, vol. 10, no. 1, pp. 66–75, 2003.
- C. Rozman and E. Montserrat, “Chronic lymphocytic leukemia,” The New England Journal of Medicine, vol. 333, no. 16, pp. 1052–1057, 1995.
- T. J. Hamblin and D. G. Oscier, “Chronic lymphocytic leukaemia: the nature of the leukaemic cell,” Blood Reviews, vol. 11, no. 3, pp. 119–128, 1997.
- M. MacFarlane, N. Harper, T. R. Snowden, et al., “Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia,” Oncogene, vol. 21, no. 44, pp. 6809–6818, 2002.
- J. E. Bolden, M. J. Peart, and R. W. Johnstone, “Anticancer activities of histone deacetylase inhibitors,” Nature Reviews Drug Discovery, vol. 5, no. 9, pp. 769–784, 2006.
- W. K. Rasheed, R. W. Johnstone, and H. M. Prince, “Histone deacetylase inhibitors in cancer therapy,” Expert Opinion on Investigational Drugs, vol. 16, no. 5, pp. 659–678, 2007.
- T. Jenuwein and C. D. Allis, “Translating the histone code,” Science, vol. 293, no. 5532, pp. 1074–1080, 2001.
- P. A. Marks, R. A. Rifkind, V. M. Richon, R. Breslow, T. Miller, and W. K. Kelly, “Histone deacetylases and cancer: causes and therapies,” Nature Reviews Cancer, vol. 1, no. 3, pp. 194–202, 2001.
- J. S. Carew, F. J. Giles, and S. T. Nawrocki, “Histone deacetylase inhibitors: mechanisms of cell death and promise in combination cancer therapy,” Cancer Letters, vol. 269, no. 1, pp. 7–17, 2008.
- R. L. vanOosten, J. K. Earel Jr., and T. S. Griffith, “Histone deacetylase inhibitors enhance Ad5-TRAIL killing of TRAIL-resistant prostate tumor cells through increased caspase-2 activity,” Apoptosis, vol. 12, no. 3, pp. 561–571, 2007.
- R. L. vanOosten, J. K. Earel Jr., and T. S. Griffith, “Enhancement of Ad5-TRAIL cytotoxicity against renal cell carcinoma with histone deacetylase inhibitors,” Cancer Gene Therapy, vol. 13, no. 6, pp. 628–632, 2006.
- S. Fulda, “Modulation of TRAIL-induced apoptosis by HDAC inhibitors,” Current Cancer Drug Targets, vol. 8, no. 2, pp. 132–140, 2008.
- R. R. Rosato, J. A. Almenara, Y. Dai, and S. Grant, “Simultaneous activation of the intrinsic and extrinsic pathways by histone deacetylase (HDAC) inhibitors and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) synergistically induces mitochondrial damage and apoptosis in human leukemia cells,” Molecular Cancer Therapeutics, vol. 2, no. 12, pp. 1273–1284, 2003.
- S. Inoue, A. Mai, M. J. S. Dyer, and G. M. Cohen, “Inhibition of histone deacetylase class I but not class II is critical for the sensitization of leukemic cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis,” Cancer Research, vol. 66, no. 13, pp. 6785–6792, 2006.
- J. K. Earel Jr., R. L. vanOosten, and T. S. Griffith, “Histone deacetylase inhibitors modulate the sensitivity of tumor necrosis factor-related apoptosis-inducing ligand-resistant bladder tumor cells,” Cancer Research, vol. 66, no. 1, pp. 499–507, 2006.
- B. Karacay, S. Sanlioglu, T. S. Griffith, A. Sandler, and D. J. Bonthius, “Inhibition of the NF-B pathway enhances TRAIL-mediated apoptosis in neuroblastoma cells,” Cancer Gene Therapy, vol. 11, no. 10, pp. 681–690, 2004.
- R. L. vanOosten, J. M. Moore, B. Karacay, and T. S. Griffith, “Histone deacetylase inhibitors modulate renal cell carcinoma sensitivity to TRAIL/Apo-2L-induced apoptosis by enhancing TRAIL-R2 expression,” Cancer Biology & Therapy, vol. 4, no. 10, pp. 1104–1112, 2005.
- M. Garofalo, G. Romano, C. Quintavalle, et al., “Selective inhibition of PED protein expression sensitizes B-cell chronic lymphocytic leukaemia cells to TRAIL-induced apoptosis,” International Journal of Cancer, vol. 120, no. 6, pp. 1215–1222, 2007.
- A. Olsson, T. Diaz, M. Aguilar-Santelises, et al., “Sensitization to TRAIL-induced apoptosis and modulation of FLICE-inhibitory protein in B chronic lymphocytic leukemia by actinomycin D,” Leukemia, vol. 15, no. 12, pp. 1868–1877, 2001.
- M. Movassagh and R. S.-Y. Foo, “Simplified apoptotic cascades,” Heart Failure Reviews, vol. 13, no. 2, pp. 111–119, 2008.
- D. R. Green and G. Kroemer, “The pathophysiology of mitochondrial cell death,” Science, vol. 305, no. 5684, pp. 626–629, 2004.
- M. J. Keating, I. Flinn, V. Jain, et al., “Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: results of a large international study,” Blood, vol. 99, no. 10, pp. 3554–3561, 2002.