Modulation of CXCR4, CXCL12, and Tumor Cell Invasion Potential In Vitro by Phytochemicals
Figure 2
Genistein downregulates CXCR4 surface expression and intracellular
CXCL12 expression. Downregulation of
CXCR4 protein expression in MCF-7, MDA-MB-231, and BG-1 cells at concentrations
of genistein ranging from 0–100 M for a 24-hour
period (a)–(c). Downregulation of intracellular CXCL12
protein expression in (a) MCF-7 and (c)
BG-1 cells at 30–100 M genistein.
Fluorescence distribution plots depict one representative experiment. Isotype controls are represented by filled
histograms. Mean fluorescence intensities (MFI) and their corresponding
standard deviations are derived from three independent experiments.
