Anti-EGFR Therapy: Mechanism and Advances in Clinical Efficacy in Breast Cancer

Figure 1

The EGFR Signaling Pathway. (a) Upon EGF-ligand binding to the EGFR there is subsequent dimerization (homo- or hetero-) and tyrosine kinase residue auto-/transphosphorylation of dimer partners, which in turn initiates the actual downstream signaling pathways. (b) Ras signaling cascade in tabulated form. (c) PI3K signaling cascade in tabulated form.