Review Article

Anti-EGFR Therapy: Mechanism and Advances in Clinical Efficacy in Breast Cancer

Table 2

Part A. Response to first-line 3-weekly Trastuzumab monotherapy from Baselga et al. [27]. CR: Complete response; PR: Partial response; SD: Stable disease; CBR: Clinical benefit rate; PD: Progressive disease; ORR: Overall response rate; ITT: Intent-to-treat population. Part B. Most common treatment-related adverse events (n = 105), adapted from Baselga et al. [27].
(a)

No. of patients
(n = 105)*

ResponseNo.%
CR22
PR1817
SD5351
CRB (CR + PR + SD > 6 months)3533
PD3029
ORR2019

*Data missing for 2 patients.
One patient with best response of SD in the main study period achieved CR in the 12-month follow-up period. Therefore, in the follow-up analysis, ORR was 20%.
(b)

No. of patients

Adverse eventNo.%
Rigors1918
Pyrexia1615
Headache1110
Nausea1010
Fatigue1010