Table 1: Demographic data for patient with multiple recurrences of well-differentiated thyroid carcinoma.

N31
Age, median (range), years43 (16–83)
Sex, M:F11:20
Histologic type
Papillary19
Follicular4
Mixed3
Tall cell5
Tumour size, median (range), cm3.3 (0.5–5.5)
Multifocal disease21
Extrathyroidal extension18
Lymphatic invasion18
Vascular invasion3
Distant metastasis6
AJCC stage
I4
II8
III11
IV8
MACIS, median (range)6.03 (3.25–11.02)
Extent of initial surgery
Subtotal thyroidectomy12
Total thyroidectomy19
Neck dissection 15
Lodine 131 therapy27
External beam radiation therapy10
Site of recurrence
Local6
Regional15
Distant6
Unspecified4
Outcome
Alive, no evidence of disease9
Alive with disease12
Dead of disease10
Dead, no evidence of disease0
Follow–up, median (range), years12.6 (9months35.5years)

AJCCAmerican JOINT Committee on Cancer.
Data is for the number of patients in each category.
central +/- lateral neck dissection.
Unspecified recurrence-elevated thyroglobulin levels in the presence of a negative clinical exam and failure of localization with imaging modalities (i.e., ultrasonography, I131 scanning, CT and MRI).