Table 1: Clinicopathological characteristics at initial diagnosis and locoregional relapse.

At diagnosisAt recurrence

Age
Median (range)65 (45–77)
Relapse-free interval (months)
Median (range)15 (5–221)
Size (cm)
Median (range)2 (0.3–6)2.6 (0.6–10)

Gender
Male41100
Family history
No2971
Yes1229
Smoking history
No252868
Yes39951332
Pack years
Median (range)52.5 (0–125)
Alcohol consumption
Low1332
Moderate1639
High1229
Symptoms
Hoarseness2663
Dyshphagia1024
Dyspnoea12
Sore mouth25
Ulceration12
Lymphadenopathy12
Primary site
Glottic2663
Supraglottic1024
Transglottic12
Oropharynx37
Unknown primary12
Site of recurrence
Local2766
Lymph nodes ± local615
Other819
T stage
T11639
T21229
T3820
T4410
Unknown12
N stage
3585
37
12
Unknown25
Grade
I717922
II18441639
III512717
IV1225
In Situ1200
Verrucous1212
Unknown820615
Surgery
Biopsy13321434
Total laryngectomy ± nodal resection10241946
Hemilaryngectomy or segmental resection81912
Local resection1024717
Radiotherapy (RT)
No20493073
Yes21511024
Unknown0012
RT dose (Gy)
Median (range)66 (64–74)69 (40–72)
Chemotherapy (CT)
No40983073
Yes121024
Unknown0012
CT duration (months)
Median (range)3.7 (1.8–5.0)
Radiotherapy only2049717
Chemotherapy only00717
Paclitaxel + gemcitabine1
Paclitaxel + liposomal doxorubicin3
Methotrexate1
Missing data2
Surgery only19461946
Chemoradiotherapy1237
Paclitaxel + gemcitabine1
Paclitaxel + liposomal doxorubicin1
Missing data1