Table 3: Association of mRNA expression the HER family genes with clinicopathological parameters.

EGFR HER2 HER3 HER4 Low High Low High Low High Low High Alcohol Consumption .577 .404 .259 .239  Low 5 (24) 8 (40) 8 (44) 5 (28) 9 (43) 4 (20) 9 (45) 4 (21)  Moderate 9 (43) 7 (35) 7 (39) 6 (33) 6 (29) 10 (50) 6 (30) 10 (53)  High 7 (33) 5 (25) 3 (17) 7 (39) 6 (29) 6 (30) 5 (25) 5 (26) Site of relapse .999 .501 .812 .545  Local only 14 (67) 13 (65) 13 (72) 13 (72) 13 (62) 14 (70) 12 (60) 15 (79)  Lymph nodes ± Local 3 (14) 3 (15) 2 (11) 4 (22) 4 (19) 2 (10) 3 (15) 2 (11)  Other 4 (19) 4 (20) 3 (17) 1 (6) 4 (19) 4 (20) 5 (25) 2 (11) Size at 1st relapse .425 .256 .145 .716    cm 4 (19) 3 (15) 3 (17) 4 (22) 4 (19) 3 (15) 3 (15) 4 (21)  2–4 cm 9 (43) 13 (65) 8 (44) 10 (56) 9 (43) 13 (66) 11 (55) 10 (53)    cm 5 (24) 2 (10) 5 (28) 1 (6) 6 (29) 1 (5) 5 (25) 2 (10)  Unknown 3 (14) 2 (10) 2 (11) 3 (17) 2 (10) 3 (15) 1 (5) 3 (16) Lymph nodes at diagnosis .999 .999 .999 .999  N0 18 (86) 18 (90) 16 (89) 16 (89) 18 (86) 18 (90) 17 (85) 17 (89)  N1-N2 2 (10) 2 (10) 2 (11) 2 (11) 2 (10) 2 (10) 2 (10) 2 (11)  Unknown 1 (5) 0 (0) 0 (0) (0) 1 (5) 0 (0) 1 (5) 0 (0) Differentiation grade at relapse .240 .417 .999 .448  Well or moderate 13 (62) 12 (60) 13 (72) 9 (50) 12 (57) 13 (65) 12 (60) 13 (81)  Poor or undifferentiated 2 (10) 7 (35) 3 (17) 5 (28) 4 (19) 5 (25) 6 (33) 3 (19)  Unknown 6 (29) 1 (5) 2 (11) 4 (22) 5 (24) 2 (10) 2 (10) 3 (16) Pack years exposure .999 .999 .999 .205   11 (52) 11 (55) 10 (56) 9 (50) 11 (52) 11 (55) 8 (40) 12 (63)   10 (48) 9 (45) 8 (44) 9 (50) 10 (48) 9 (45) 12 (60) 7 (37) Age .217 .094 .538 .752   13 (62) 8 (40) 12 (67) 6 (33) 12 (57) 9 (45) 11 (55) 9 (47)   8 (38) 12 (60) 6 (33) 12 (67) 9 (43) 11 (55) 9 (45) 10 (53) Diagnosis to recurrence Interval .530 .305 .341 .748   months 7 (33) 9 (45) 9 (50) 5 (28) 10 (48) 6 (30) 9 (45) 7 (37)   months 14 (67) 11 (55) 9 (50) 13 (72) 11 (52) 14 (70) 11 (55) 12 (63)