Table 3: Association of mRNA expression the HER family genes with clinicopathological parameters.

EGFR HER2 HER3 HER4
LowHigh LowHigh LowHigh LowHigh

Alcohol Consumption.577.404.259.239
Low5 (24)8 (40)8 (44)5 (28)9 (43)4 (20)9 (45)4 (21)
Moderate9 (43)7 (35)7 (39)6 (33)6 (29)10 (50)6 (30)10 (53)
High7 (33)5 (25)3 (17)7 (39)6 (29)6 (30)5 (25)5 (26)
Site of relapse.999.501.812.545
Local only14 (67)13 (65)13 (72)13 (72)13 (62)14 (70)12 (60)15 (79)
Lymph nodes ± Local3 (14)3 (15)2 (11)4 (22)4 (19)2 (10)3 (15)2 (11)
Other4 (19)4 (20)3 (17)1 (6)4 (19)4 (20)5 (25)2 (11)
Size at 1st relapse.425.256.145.716
 cm4 (19)3 (15)3 (17)4 (22)4 (19)3 (15)3 (15)4 (21)
2–4 cm9 (43)13 (65)8 (44)10 (56)9 (43)13 (66)11 (55)10 (53)
 cm5 (24)2 (10)5 (28)1 (6)6 (29)1 (5)5 (25)2 (10)
Unknown3 (14)2 (10)2 (11)3 (17)2 (10)3 (15)1 (5)3 (16)
Lymph nodes at diagnosis.999.999.999.999
N018 (86)18 (90)16 (89)16 (89)18 (86)18 (90)17 (85)17 (89)
N1-N22 (10)2 (10)2 (11)2 (11)2 (10)2 (10)2 (10)2 (11)
Unknown1 (5)0 (0)0 (0)(0)1 (5)0 (0)1 (5)0 (0)
Differentiation grade at relapse.240.417.999.448
Well or moderate13 (62)12 (60)13 (72)9 (50)12 (57)13 (65)12 (60)13 (81)
Poor or undifferentiated2 (10)7 (35)3 (17)5 (28)4 (19)5 (25)6 (33)3 (19)
Unknown6 (29)1 (5)2 (11)4 (22)5 (24)2 (10)2 (10)3 (16)
Pack years exposure.999.999.999.205
11 (52)11 (55)10 (56)9 (50)11 (52)11 (55)8 (40)12 (63)
10 (48)9 (45)8 (44)9 (50)10 (48)9 (45)12 (60)7 (37)
Age.217.094.538.752
13 (62)8 (40)12 (67)6 (33)12 (57)9 (45)11 (55)9 (47)
8 (38)12 (60)6 (33)12 (67)9 (43)11 (55)9 (45)10 (53)
Diagnosis to recurrence Interval.530.305.341.748
months7 (33)9 (45)9 (50)5 (28)10 (48)6 (30)9 (45)7 (37)
months14 (67)11 (55)9 (50)13 (72)11 (52)14 (70)11 (55)12 (63)